Dysfunctional MItochondria directly proVoke INflammation in Pre-Eclampsia

Pre-eclampsia is proposed to result from placental ischaemia induced by a reduction in uteroplacental perfusion, which consequently exposes the placenta to elevated levels of oxidative stress. There is a growing body of evidence indicating that mitochondrial dysfunction acts as a pathogenic mediator of oxidative stress in pre-eclampsia. 

 

 

pregnant lady sitting

DIVINE aims to develop a novel therapy for pre-eclampsia

The initial objective of DIVINE is to cultivate a method to predict those at risk by combining clinical markers previously identified with serum profiles of both mitochondrial dysfunction/stress and inflammation in women recruited to the Screening for Pregnancy Endpoints (SCOPE) study of low-risk nulliparous women. Additionally, DIVINE aims to develop a novel therapy for pre-eclampsia by directly targeting mitochondrial superoxide scavenging using both in vitro and in vivo models of disease.

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