Dr. Shirish Yakkundi

Dr. Shirish Yakkundi
SFI Funded Investigator; Metabolomics – Mass Spectrometry Lead Scientist

Shirish's research interests are in the area of Metabolomics – Untargeted and Targeted (Preterm Birth and Preeclampsia); LC-MS QTOF and LC-MS/MS (triple quad); Lipids and polar compounds extraction; reverse phase and HILIC chromatography; Use of Progenesis QI software to accurately quantify and identify the compounds in the biological samples; Dried Blood Spots (DBS) sampling and analysis; Bioanalysis – Analytical method development and validation (FDA and ICH guidelines); Paediatric and neonatal blood (plasma and DBS) analysis; Quantification of excipients, off-labelled and unlicensed paediatric medicines; and Pharmacokinetics.

Career Profile:

  • 2015 Present SFI funded investigator, Research Scientist Metabolomics
  • 2014 Present Visiting Fellow, School of Pharmacy; PK-PD laboratory; Queen’s University Belfast, UK
  • 2005 – 2014 Research Fellow; School of Pharmacy; PK-PD laboratory; Queen’s University Belfast, UK
  • 2000 – 2005 Research Fellow; Veterinary Sciences Division; Chemical Surveillance Department, Queen’s University Belfast, UK

Educational Qualifications:

  • Certificate in Management Studies & Diploma in Management; Queen’s University Belfast (UK)
  • Ph.D - Analytical and Natural Products Chemistry; University of Mysore (India)
  • M.Sc – Organic Chemistry; University of Bombay (India)
  • B.Sc – Chemistry; University of Bombay (India)

Professional Activities/Achievements:

  • Member of Royal Society of Chemistry (MRSC)                                                           
  • Member of American Society for Mass Spectrometry (ASMS)
  • Member of British Mass Spectrometry Society (BMSS)                         

Involved in successful designing, planning, implementation and completion of the following projects

  1. European Study of Neonatal Excipient Exposure (ESNEE) in collaboration with hospitals in UK, France and Estonia– Priomed, EU, funded by MRC in the UK
  2. Development of Dried Blood Spots (DBS) analysis platform, which involved developing and validating bioanalytical assays to quantify drugs and excipients from DBS obtained from paediatric/neonatal patients using LC-MS/MS - Core funding for the PKPD laboratory, Queen’s University Belfast and HSC R & D Office, Northern Ireland
  3. Addressing a major inequality in children, Access to evidence based medicines; to study the use of unlicensed and off-labelled medicines in the paediatric population – Funded by HSC R & D Office, Northern Ireland
  4. Analysis of Veterinary drug residues -  European Commission Framework 5

Involved in the implementation of Neonatal and Paediatric Pharmacokinetics of Antimicrobials (NAPPA) project in collaboration with St George's University of London

Key Publications:

  1. Yakkundi S, Mulla H, Pandya H, Turner MA, McElnay J; Quantitative analysis of methyl and propyl parabens in neonatal DBS using LC-MS/MS. Bioanalysis, 2016, 8(11):1173-1182.       
  2. Pandya HC, Mulla H, Hubbard M, Cordell RL, Monks PS, Yakkundi S, McElnay JC, Nunn AJ, Turner MA; ESNEE consortium; Essential medicines containing ethanol elevate blood acetaldehyde concentrations in neonates. Eur J Pediatr. 2016, 175(6):841-847.
  3. Mulla H, Yakkundi S, McElnay J, Lutsar I, Metsvaht T, Varendi H, Nellis G, Nunn A, Duncan J, Pandya H, Turner M; An observational study of blood concentrations and kinetics of methyl- and propyl-parabens in neonates. Pharm Res. 2015, 32(3):1084-1093.
  4. Turner MA, Duncan JC, Shah U, Metsvaht T, Varendi H, Nellis G, Lutsar I, Yakkundi S, McElnay JC, Pandya H, Mulla H, Vaconsin P, Storme T, Rieutord A, Nunn AJ. Risk assessment of neonatal excipient exposure: Lessons from food safety and other areas. Advanced Drug Delivery Reviews, 2014, 73, 89-101.
  5. Hawwa AF, Westwood PM, Collier PS, Millership JS, Yakkundi S, Thurley G, Shields MD, Nunn AJ, Halliday HL, McElnay JC. Prophylactic ranitidine treatment in critically ill children - a population pharmacokinetic study. British Journal of Clinical Pharmacology, 2013, 75(5), 1265-1276.

Patents

A new chromatographic process for the separation of azadirachtin. Patent filed in India (IN Appl. 95/MAI,120), August 1995 and in Canada, Can. Pat. Appl. CA 2,184,564 (Cl CO 7H7/06), March 1997.

 

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