Comms, Author at INFANT

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Better conversations could strengthen stillbirth-prevention efforts

By Comms|2026-09-17T11:10:02+01:00July 14th, 2026|

Better conversations could strengthen stillbirth-prevention efforts

A University College Cork study led by researchers from the National Perinatal Epidemiology Centre, the Pregnancy Loss Research Group at INFANT Research Centre and the School of Public Health, highlights missed opportunities to reduce stillbirth risk in Ireland.

Every parent wants to do everything they can to give their baby the best possible start.

Yet new research from University College Cork has found that while most women know they should go to sleep on their side during late pregnancy, many are never told why it matters.

The national study, involving almost 800 women across Ireland, is the first to examine awareness of maternal sleep position recommendations in Ireland and the behavioural factors that influence whether women follow them.

A simple action with the potential to reduce stillbirth

International evidence has shown that going to sleep on your side from 28 weeks of pregnancy is associated with a lower risk of stillbirth.

The research found that although most women recognised side sleeping as the recommended position, only around six in ten understood that the advice is linked to reducing stillbirth risk. Even more concerning, discussions about stillbirth were rarely part of conversations with healthcare professionals.

Instead, many women first encountered this information through websites, social media or pregnancy apps rather than through routine maternity care.

Knowledge was strongly associated with behaviour

The study found that women who correctly understood the recommendations were more than four times more likely to adopt the advised sleep position.

Researchers also found that women were most motivated to follow the advice when they understood it was better for their baby, highlighting the importance of explaining not just what to do, but why it matters.

Informing future public health action

The findings suggest that improving awareness is not simply about providing more information.

Instead, consistent messaging, earlier conversations during pregnancy, and practical advice that helps women manage common challenges such as reflux or discomfort could improve adherence to sleep position recommendations.

The researchers suggest these findings could help inform future national public health campaigns and maternity care guidance aimed at reducing preventable stillbirths in Ireland.

Research at a glance

Research focus
Understanding women’s knowledge and behaviours around sleep position during late pregnancy.

Participants
769 women who had given birth in Ireland within the previous two years.

Key findings

Most women knew they should go to sleep on their side, but many did not understand the link with stillbirth prevention.
More than one-third reported receiving no advice about sleep position during pregnancy.
Women who understood the recommendations were over four times more likely to follow them.
Much of the information women received came from non-clinical sources rather than healthcare professionals.
Earlier, clearer and more consistent communication could strengthen stillbirth prevention efforts.

Read the full study here.

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Giving premature babies a stronger start: how PremSmart transformed neonatal nutrition in Ireland

By Comms|2026-09-17T11:06:21+01:00July 7th, 2026|

Giving premature babies a stronger start: how PremSmart transformed neonatal nutrition in Ireland

For babies born too soon, the first days of life are critical. During this period, nutrition plays a critical role in brain development, growth and long-term health. But for many years, delivering that nutrition safely and consistently was one of the most complex challenges in neonatal care.

Clinicians relied on a highly individualised approach to intravenous nutrition, prescribing nutrients one by one. It was complex, time-consuming and difficult to standardise. In fast-changing environments, delays between prescribing and delivery meant that by the time nutrition reached a baby, their needs could already have changed. Even when everything worked as intended, many babies experienced gaps in nutrition during this crucial stage.

From research to practice

PremSmart was developed to address this challenge.

PremSmart combines specially designed intravenous nutrition formulations with a decision-support system that helps clinicians match nutrition more closely to a baby’s changing needs.

The work began through research closely connected to clinical practice, shaped by the challenges faced in neonatal units. Developed through collaboration between the INFANT Research Centre and the Health Service Executive (HSE), the system is designed to support babies through one of the most complex stages of care — when they transition from intravenous feeding to milk.

National impact

Today, PremSmart is used in neonatal units across Ireland and has become part of routine care in the majority of cases. This level of national adoption is rare, particularly for something as complex as intravenous nutrition.

This is reflected in how it is now used in practice across neonatal units.

Prof Anne Doolan, Consultant Neonatologist at The Coombe Hospital, says:

“We use the PremSmart program every day in our Neonatal Unit. It has standardised practice which means that every baby gets excellent nutritional care.”

Babies are now more consistently reaching recommended nutritional levels during this early stage, supporting better growth. For healthcare teams, the system simplifies a previously complex process, reducing variation and easing workload. For the health service, it has delivered efficiencies, including cost savings of around €1 million per year.

For families, the impact is less visible but just as important. Parents of preterm babies must place enormous trust in clinical teams during an already overwhelming time. Knowing that care is supported by a consistent, well-designed system offers reassurance when so much else feels uncertain.

Clíona O’Donoghue, whose daughter Sadhbh was born at 26 weeks, describes the experience:

“My daughter Sadhbh was born at 26 weeks, weighing just 2 lbs 3 oz. The neonatal journey can be overwhelming, and we placed complete trust in the team caring for her. We lived from one weigh-in to the next, seeing every gram gained as a sign of progress and hope.

Knowing she was receiving the right nutrition at such a critical stage made a huge difference. Any advancement that improves outcomes for these tiny babies and helps families feel more connected to their child’s journey, is invaluable.”

From implementation to policy

PremSmart also highlights an important part of healthcare innovation: ensuring that new approaches work in real-world settings and can be sustained over time.

Experiences in other countries have shown that scaling up new nutrition systems can carry risks if not carefully managed. In response, the PremSmart programme has focused not only on developing the system, but also on understanding how it works in practice — including training, support and day-to-day use.

This work is now helping to inform how the system is supported nationally, from training to audit and oversight. In doing so, PremSmart is beginning to shape how this type of care is delivered and maintained across the health service.

A model for impact

PremSmart is more than a single innovation. It shows how research, when closely connected to clinical practice, can lead to real and lasting change.

The next phase is already underway. PremSmart 2.0 is being developed as a digital platform, with the potential to further support decision-making and open up new ways of involving parents in their baby’s care.

At its heart, this work is about giving preterm babies the best possible start in life. It demonstrates how research embedded in frontline healthcare can move beyond discovery to reshape care for some of the health service’s most vulnerable patients.

About the research team

Dr Ann-Marie Brennan

Co-Founder Neonatal Clinical Nutrition Research Group and Lead Investigator, INFANT Research Centre

Clinical Specialist Neonatal Dietitian, Cork University Maternity Hospital

Dr Brennan is an established researcher in preterm nutrition with over 25 years of clinical and academic experience. She leads the development, validation and national implementation of PremSmart.

Sarah Fenton

Co-Founder Neonatal Clinical Nutrition Research Group, INFANT Research Centre

Advanced Specialist Neonatal Pharmacist, Cork University Maternity Hospital / Cork University Hospital

Sarah Fenton has over 20 years clinical experience with expertise in preterm nutrition, health informatics and implementation science. She co-leads the development and validation of PremSmart, and is conducting the national evaluation of its implementation.

Together, they lead the Neonatal Clinical Nutrition Research Group at INFANT, focusing on translating research into innovative solutions at the cot-side and delivering measurable improvements in outcomes for babies and the health service.

Advancing maternal and child health through better data

Advancing maternal and child health through better data

By Comms|2026-07-07T15:27:37+01:00July 7th, 2026|

Advancing maternal and child health through better data

Reliable, high-quality health data is essential for improving care for mothers, babies and children. But when health information is collected differently across countries or systems cannot communicate with one another, it becomes harder to monitor outcomes, inform clinical decisions and generate the evidence needed to strengthen healthcare.

As part of the Horizon Europe-funded LINDA-FAMILIA project, researchers and health system partners from Ethiopia, Rwanda, Uganda and Tanzania recently came together in Addis Ababa to advance a shared approach to data harmonisation and interoperability across maternal, newborn and child health systems.

Professor Ali Khashan from INFANT Research Centre at University College Cork provided technical leadership during the workshop, leading sessions focused on improving the comparability of maternal health data across participating countries. Working with project partners, participants reviewed existing data collection systems, identified common data elements, explored opportunities for federated research, and developed a regional roadmap for harmonising health data in line with World Health Organization recommendations.

Alongside this work, technical sessions explored how Electronic Medical Record (EMR) systems can better integrate with District Health Information Software 2 (DHIS2), helping countries strengthen digital health infrastructure, improve reporting and support more informed clinical and policy decision-making.

This workshop marks another important milestone for the LINDA-FAMILIA project as partners work together to build interoperable digital health systems that improve maternal, newborn and child health across East Africa.

Read the full workshop report from the Ethiopian Public Health Institute here.

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Preparing for the next pandemic: Lessons from COVID-19, pregnancy and the power of better data

By Comms|2026-09-17T11:05:26+01:00July 2nd, 2026|

Preparing for the next pandemic: Lessons from COVID-19, pregnancy and the power of better data

While COVID-19 may no longer dominate headlines, the lessons learned during the pandemic continue to shape how healthcare systems prepare for future public health emergencies. This is particularly true when it comes to protecting pregnant women and their babies.

When COVID-19 emerged, pregnant women faced uncertainty at every turn. Questions about infection risks, vaccine safety, and the potential impact on unborn babies created anxiety for expectant mothers and challenges for healthcare professionals trying to provide evidence-based guidance in real time.

In the early stages of the pandemic, reliable evidence on the safety and effectiveness of COVID-19 vaccination during pregnancy was limited internationally. In Ireland, only 58% of new and expectant mothers had received a COVID-19 vaccine, while studies from the United Kingdom suggested that unvaccinated pregnant women infected with COVID-19 were more likely to require intensive care treatment.

“Monitoring COVID-19 infection and vaccination during pregnancy is important because we know that during pregnancy a woman can be at greater risk of becoming severely ill from the virus,” explains Professor Ali Khashan, Principal Investigator at INFANT, and Professor in Epidemiology in the School of Public Health, UCC.

“When a vaccine becomes available, there is another question – should pregnant women take the vaccine or not?”

To help answer these questions, researchers from INFANT Research Centre at University College Cork (UCC), in partnership with Ulster University, launched the COVICAT project to better understand COVID-19 infection and vaccination during pregnancy across the island of Ireland.

While the project set out to answer questions about COVID-19 in pregnancy and risk of congenital anomalies, it also uncovered a broader challenge. Researchers found that important health information was often difficult to access and connect across systems, limiting the ability to rapidly generate evidence for pregnant women, clinicians and policymakers during a public health crisis.

One reason these findings matter is that pregnant women are generally excluded from clinical trials of new medicines and vaccines.

Dr Mary O’Mahony, Consultant in Public Health Medicine and collaborator on the project, explains:

“Projects such as COVICAT highlight the importance of robust data systems that allow us to monitor the safety and effectiveness of public health interventions during pregnancy and provide reassurance for women and the healthcare professionals caring for them.”

Reflecting on the project’s wider implications, Dr O’Mahony adds that “validated routine surveillance data can inform pandemic response to improve outcomes.”

Without access to high-quality population data, generating timely evidence during a public health emergency becomes significantly more difficult.

Researchers sought to better understand patterns of COVID-19 infection and vaccine uptake during pregnancy across the island of Ireland, and explore whether infection or vaccination was associated with congenital anomalies during foetal development.

By comparing systems north and south of the border, the researchers identified major differences in how maternal health data was collected, linked and used for research. In Northern Ireland, unique Health and Care identification numbers allowed maternity, infection, and vaccination records to be connected across healthcare databases, enabling population-level research.

In contrast, researchers encountered significant challenges accessing comparable data in the Republic of Ireland. Pregnancy status was not consistently recorded across vaccination and infection databases, while fragmented systems and limited data linkage made it difficult to answer urgent public health questions quickly during a rapidly evolving pandemic.

The lessons from COVICAT were subsequently translated into peer-reviewed publications and a policy brief, which outlined practical recommendations to improve data access, linkage and maternal health surveillance. These recommendations included accelerating the implementation of Individual Health Identifiers (IHIs), strengthening data linkage across healthcare systems and streamlining access to population health data for research and public health decision-making.

“In our experience of seeking to access data about pregnancy and COVID-19 infection and vaccination, once we were put in touch with the right individuals, they were very helpful,” says Professor Khashan. “But there are systemic issues that need to be addressed for the data to be useful for delivering better healthcare.”

Beyond identifying gaps in the system, the project demonstrated how better data can directly support patients and clinicians during future health emergencies.

“Better collection and use of data would help the healthcare system to prepare initially and then monitor the health of these populations during an emergency,” says Professor Khashan. “This would provide reliable evidence to inform timely public health interventions and support to help them.”

For pregnant women and healthcare professionals, this means faster access to the evidence needed to make informed decisions during future public health emergencies.

The project’s European analysis, using EUROCAT data, is expected to contribute valuable evidence around COVID-19 infection, vaccination uptake, and risk of congenital anomalies, helping clinicians provide informed advice and reassuring pregnant women who may have concerns about vaccination.

The work reinforced the importance of cross-border collaboration in addressing shared healthcare challenges. The partnership brought together expertise in public health, epidemiology, maternal health, congenital anomaly surveillance and health data research from both sides of the border.

“The all-island approach was critical because infections know no borders,” says Dr Maria Loane, Leader of the Centre for Maternal, Fetal an Infant Research at Ulster University and Co-Principal Investigator of COVICAT. “Bringing together expertise and data from both jurisdictions allowed us to compare healthcare systems, identify important gaps and demonstrate why stronger maternal health data infrastructure will be essential for responding to future pandemics and public health emergencies.”

The collaboration demonstrated how research partnerships can help identify shared challenges, accelerate learning and generate evidence that improves healthcare policy and future pandemic preparedness.

Although the pandemic has passed, the lessons from COVICAT remain highly relevant. The project demonstrated that protecting pregnant women and babies during public health emergencies requires not only scientific expertise, but also accessible health data, strong research partnerships and collaboration across healthcare systems.

Through collaborative research and all-island partnership, COVICAT has helped strengthen understanding of how health systems can better support pregnant women, clinicians and policymakers during times of crisis, while helping to build more resilient healthcare systems for the future.

Further reading

COVICAT was recently featured in the Higher Education Authority’s North South Research Programme: Insights on Impact report, which showcases the impact of all-island research collaborations.

From Evidence to Impact: Dr Chrsitine Cassidy Opens UCC Futures Children Seminar Series

From Evidence to Impact: Dr Chrsitine Cassidy Opens UCC Futures Children Seminar Series

By Comms|2026-05-20T12:53:02+01:00May 20th, 2026|

The inaugural UCC Futures Children seminar of the year brought together researchers, clinicians, academic and professional staff, and others interested in improving outcomes for children and families.

Opening the event, Professor Geraldine Boylan, Director of UCC Futures Children and INFANT Research Centre, highlighted the importance of creating stronger connections across disciplines at University College Cork (UCC), recognising that children’s outcomes are shaped not only by healthcare, but by education, family supports, environment and wider social systems.

Reflecting on the importance of implementation and impact, Professor Boylan noted:

“If we can’t implement research into practice, policy, systems or technology, what was the point of doing it in the first place?”

The keynote lecture was delivered by Dr Christine Cassidy, Associate Professor at Dalhousie University and Clinician Scientist specialising in child health at IWK Health. Introduced by Dr Rachel Flynn, School of Nursing, UCC, Dr Cassidy explored why implementation science and knowledge translation are essential to ensuring research delivers real-world change.

A central theme of the talk was the persistent gap between research and practice. Cassidy highlighted that despite the volume of healthcare research produced globally, evidence does not always translate into practice or policy, while some care delivered may still be low-value or even harmful.

Dr Cassidy emphasised that implementation should not be considered an afterthought once research is complete.

“We need to design research with implementation and impact in mind from the very beginning.”

Throughout the seminar, Dr Cassidy highlighted the importance of research co-production approaches that involve researchers, clinicians, patients, families and communities throughout the research process to ensure findings are relevant, usable and sustainable in real-world settings.

Drawing on examples from her work at the IWK Health Centre, Dr Cassidy demonstrated how collaborative implementation approaches can successfully bridge the gap between evidence and practice, particularly in improving transitions from paediatric to adult healthcare services.

Key themes that emerged from the talk included:

Embedding implementation and impact planning into research from the outset
Building stronger partnerships between researchers, clinicians, patients and families
Developing implementation science capacity within health systems
Creating “learning health systems” that continuously connect data, research and care
Ensuring equity and sustainability are integrated throughout implementation processes

Dr Cassidy also shared practical examples from her own implementation science research throughout the seminar, illustrating how evidence can be successfully translated into practice. Her presentation, including links to related publications and projects, has kindly been shared here: UCC Futures Children – Christine Cassidy Presentation 2026

The seminar reinforced the vision behind UCC Futures Children: bringing together expertise across disciplines to support research that not only advances knowledge, but creates measurable improvements in children’s lives.

Building stronger evidence for better maternal and child health in East Africa

Building stronger evidence for better maternal and child health in East Africa

By Comms|2026-05-06T14:16:53+01:00May 6th, 2026|

Building stronger evidence for better maternal and child health in East Africa

By Jimmy Patrick, Alunyo PhD fellow, Uganda

Every day across East Africa, thousands of pregnant women miss antenatal care appointments not because they do not care, but due to barriers such as distance, cost, competing responsibilities, or simply forgetting. When these visits are missed, early warning signs such as infections, high blood pressure, or pregnancy complications go unnoticed, putting both mothers and babies at risk.

Improving maternal and child health depends on stronger health systems. It requires stronger evidence to guide care, policy, and innovation.

That is why the LINDA-FAMILIA Project brought together nine PhD students and one postdoctoral researcher in Kigali, Rwanda for a four-day intensive training on systematic review and meta-analysis.

The training, held from 20-24 April 2026, focused on helping students build and bring together evidence across different areas of the project, particularly within Work Package 3 (Intervention Evaluation) and Work Package 4 (Clinical Research). Throughout the week, participants developed practical skills in writing research protocols, searching scientific literature, extracting and reviewing data, and analysing results using Review Manager (RevMan).

The workshop also extended beyond the classroom. Through visits to Rwanda’s National Health Intelligence Center, students saw how health data is used in real healthcare settings to support decision-making.

For many, the training shifted how they think about research.

Reflecting on the week, PhD student Espoir shared that one of his biggest lessons was the importance of reading more deeply and intentionally. For him, understanding the existing literature is not just a requirement for PhD proposal development, but the foundation for identifying gaps and building stronger research questions.

For PhD student Jimmy, the training built confidence in assessing the quality of research.

“The training increased my confidence in assessing the quality of evidence using tools like the Cochrane Risk of Bias Tool and the Newcastle-Ottawa Scale, understanding heterogeneity, and conducting subgroup analysis. These skills will directly support the scoping review we are conducting under WP4.”

PhD students Jimmy, Hiwot and Rehema, are currently working on a review exploring the use of SMS reminders in maternal healthcare across East Africa. This work will help inform one of LINDA-FAMILIA’s upcoming clinical trials.

Looking ahead, Professor Ali Khashan encouraged students to continue building their skills in epidemiology and biostatistics, stay connected with supervisors, start writing early, and prepare abstracts for the upcoming EDCTP Conference in Madrid.

Special thanks go to Dr Gillian Maher for leading much of the training and to the Rwanda team for hosting a productive week of learning, reflection, and collaboration.

At the heart of the LINDA-FAMILIA project is a focus on strengthening researchers, because better evidence can lead to better care for mothers, babies, and families across East Africa.

The gender gap in autism: why we need to do better for girls

The gender gap in autism: why we need to do better for girls

By Comms|2026-04-02T09:25:18+01:00April 2nd, 2026|

The gender gap in autism: why we need to do better for girls

Autism diagnosis can be a long and complex process. For some children, assessment takes years. Girls in particular are often identified much later than boys, sometimes not until adolescence meaning they can miss years of support when it matters most.

At the INFANT Research Centre in University College Cork, Dr Jane English is investigating whether biological signals present at birth could help change that timeline.

Her research focuses on identifying early-life biomarkers that may one day support earlier identification of autism, particularly those who could benefit from additional monitoring and support.

The aim is not to diagnose autism at birth, but to build the scientific foundation for earlier screening. If successful, this work could help reduce delays in identification and ensure more children, especially girls, receive support earlier in life.

“The overarching goal is to facilitate early intervention in children with autism.” English explains. “At the moment, diagnosis is complex, and quite often children are not diagnosed until the ages of four or five, and in some cases, much later”.

A system under pressure

In Ireland, autism diagnosis typically involves a multidisciplinary team assessment. While comprehensive, the system is under significant strain.

“There are thousands of families on waiting lists for a first-time autism assessment, with waiting times exceeding two years,” English says. “It is extremely challenging for families.”

Early intervention services such as speech and language therapy, occupational therapy and structured parent support can significantly improve a child’s development and quality of life.

However, timing is only part of the challenge. Gender also plays a role in when and how autism is recognised.

Why girls with autism are often missed

“We tend to catch boys earlier than girls,” English says. “The diagnostic criteria were largely designed around male-dominated profiles, and some females with autism do not fit this pattern.”

While boys may show more outward behaviours that are easier to recognise, girls are more likely to internalise their difficulties. They may appear shy or anxious while masking social discomfort and sensory challenges. As a result, their needs often go unnoticed, or they are misdiagnosed with anxiety or depression.

Recent research suggest that Autism is just as common in girls as in boys, yet boys are up to four times more likely to be diagnosed in childhood.

“The girls are there, but the system is just failing to see them” says English. “Delaying a diagnosis does not mean she is ‘fine’. It means she misses crucial support.”

This gap also affects research. Studies have historically focused more on males, limiting understanding of how autism presents biologically in females. Expanding female-focused research is therefore central to improving identification and support.

Investigating early-life biology

We know autism begins in the womb. That is why Dr English’s research focuses on the prenatal environment and the interaction between mother, placenta, and fetus.

Her team studies maternal cord blood collected immediately after delivery to identify molecular patterns linked to later autism diagnosis.

“We are looking for a molecular signature, like a fingerprint, in cord blood at birth,” explains Aisling Noone, a final year PhD student in the Department of Anatomy & Neuroscience.

Using large bio-banked pregnancy cohorts, researchers compare samples from children who later received an autism diagnosis and compare them with neurotypical children. This allows them to identify biological pathways associated with neurodevelopment.

This work is still in the discovery and validation phase.

“This type of research takes time,” English says. “The priority is to understand the biology properly and to replicate findings across populations.”

The team is particularly interested in inflammation and steroid biology during pregnancy. These factors alone cannot predict autism, but alongside genetic susceptibility they may offer important clues about how early development shapes later outcomes.

Understanding complexity

Autism is influenced by a complex interplay of genetic, biological and environmental factors. Rather than focusing on single markers, English’s team integrates multiple layers of information to help predict outcome.

This includes biomarker data alongside maternal clinical information such as mental health, stress, pregnancy complications, infection, and infant birth weight. Machine learning models are then used to explore how these factors interact.

“Instead of stripping away complexity, we incorporate it,” she says. “If something is going to be useful in practice, it has to work in the real world.”

This approach represents a shift towards understanding networks of risk and resilience, rather than searching for a single defining cause.

From discovery to responsible translation

The long-term ambition is not to provide a definitive diagnosis at birth. English is careful to draw that distinction.

“If the evidence supports it, this could one day contribute to a voluntary approach that helps families understand their child’s needs earlier.” English says.

In principle, such a system might resemble existing newborn screening frameworks, where parents opt in and receive information that supports monitoring and follow-up. Any future screening pathway would require extensive validation, ethical evaluation and close collaboration with clinicians and families.

For now, the work remains focused on strengthening the scientific evidence.

Looking ahead

Translating biomarker research into screening tools will take time, larger datasets, and continued collaboration across research and clinical communities. Expanding female-focused studies will also be essential so future approaches reflect the full diversity of how autism presents.

Much remains to be understood about how early biological signals relate to later neurodevelopment. But by investigating the earliest stages of life, this research is helping to build a stronger foundation for earlier identification.

Over time, these advances could help ensure that fewer children wait years for answers, and that girls who are currently overlooked are recognised earlier and supported sooner.

Acknowledgements:

This research was supported by the Irish Health Research Board (HRB) through an award to Dr Jane English.

For those interested in following this research or supporting future work in this area, please contact Merrin Browne, Research Engagement and Partnerships Manager, at merrinbrowne@ucc.ie or help support future research here.

Supporting parents through pregnancy loss with compassion and consistency

Supporting parents through pregnancy loss with compassion and consistency

By Comms|2026-03-25T08:03:04+00:00March 24th, 2026|

Supporting parents through pregnancy loss with compassion and consistency

Pregnancy loss and perinatal death are among the most devastating experiences a family can face. At such a time, parents need not only empathy, but clear, consistent support. Yet historically, the care families received in Ireland varied widely depending on where and how their baby died, adding uncertainty and distress to an already painful experience.

INFANT Principal Investigator Professor Keelin O’Donoghue, alongside colleagues in the Pregnancy Loss Research Group, led the development of the HSE National Standards for Bereavement Care Following Pregnancy Loss and Perinatal Death in response to this gap.

Developed following recommendations from the 2013 investigation into the death of Savita Halappanavar, the standards were designed to ensure that every parent, regardless of where they receive care, is met with compassion, dignity, and respect.

Launched nationally in 2016 after an extensive multidisciplinary development process, the standards provide a clear, evidence-based framework for maternity services. They support parents experiencing all forms of pregnancy loss, from early miscarriage to stillbirth, neonatal death, and life-limiting fetal diagnoses.

Designed as a resource for both healthcare professionals and parents, the standards guide every aspect of care. This includes how difficult news is communicated, how parents are supported in decision-making, opportunities for memory-making, and the provision of follow-up and longer-term bereavement support. They also recognise the emotional impact on healthcare staff and emphasise the importance of structured supports for those delivering care.

Researchers from the Pregnancy Loss Research Group have remained central to this work beyond development. They have helped drive national implementation across all maternity units in Ireland, contributing to training, audits, education programmes, and the creation of resources such as the national pregnancy and infant loss website. Their research has directly shaped key areas including communication, staff support, care after stillbirth, pregnancy after loss, and support following diagnoses of life-limiting fetal conditions.

By embedding compassion into national practice, these standards have transformed bereavement care in Ireland. Parents are now more likely to receive consistent, sensitive support at every stage of their journey, while healthcare professionals are better equipped to respond to both the immediate and long-term needs of bereaved families.

This work continues to evolve, with ongoing research and national oversight ensuring that care keeps improving. At its core is a simple but vital goal: that no parent faces pregnancy loss without the understanding, support, and dignity they deserve.

Biomarkers to enable early treatment of newborn brain injury

Biomarkers to enable early treatment of newborn brain injury

By Comms|2026-03-25T08:03:30+00:00March 24th, 2026|

Biomarkers to enable early treatment of newborn brain injury

Lack of oxygen to the brain at birth affects almost 200 babies in Ireland each year and more than two million infants globally. This condition, known as hypoxic ischaemic encephalopathy (HIE), is a leading cause of newborn death and long-term neurological disability, including cerebral palsy.

Early diagnosis is critical, as treatments such as therapeutic hypothermia, or brain cooling as its often known, must be initiated within a narrow time window to reduce brain injury and improve outcomes. Yet identifying which babies will benefit from treatment remains a major clinical challenge.

Researchers at INFANT, working with collaborators at University College Cork and the Karolinska Institute in Sweden, identified and validated two blood-based biomarkers that can aid the early detection of birth-related brain injury. These biomarkers are microRNAs, small strands of genetic material found in umbilical cord blood, which were shown to be significantly reduced in newborns with HIE.

The research, led by INFANT Researcher, Professor Deirdre Murray, and involving umbilical cord blood samples from 170 newborn babies in Ireland and Sweden, demonstrated consistent biological patterns across populations, strengthening their potential clinical relevance.

As Professor Murray explains:

“Early diagnosis is critical in babies affected by hypoxic ischaemic encephalopathy. Our research shows consistent biological signals across different populations, which is a vital step towards identifying brain injury when treatment decisions matter most.”

By providing an early biological signal of injury, these biomarkers could support faster identification of infants who need urgent intervention and help guide transfer to specialist centres for brain cooling therapy.

INFANT Director Professor Geraldine Boylan highlights the broader significance of the work:

“This research demonstrates how sustained, collaborative effort can advance neonatal care. It reflects INFANT’s commitment to developing evidence that has real potential to improve outcomes for babies and families.”

Supported by funding from the Health Research Board and the National Children’s Research Centre, this research represents almost a decade of focused investigation into early brain injury. It is an important step towards improving diagnosis and care for newborns affected by HIE.

Predicting pre-eclampsia before it becomes dangerous

Predicting pre-eclampsia before it becomes dangerous

By Comms|2026-03-25T08:04:00+00:00March 24th, 2026|

Predicting pre-eclampsia before it becomes dangerous

For many women, pre-eclampsia arrives without warning. What begins as a healthy pregnancy can suddenly become life-threatening, with serious consequences for both mother and baby. Despite affecting around 5% of first-time mothers, clinicians have had limited tools to predict who will develop the condition.

INFANT researchers aimed to change that uncertainty.

Using advanced metabolomic technologies, the team studied subtle changes in blood chemistry during pregnancy and identified a unique set of biomarkers linked to the later development of pre-eclampsia. These biomarkers make it possible to identify women at risk before clinical symptoms appear.

Early prediction changes everything. Women identified as high-risk can be monitored more closely, receive preventative treatments, and make informed decisions alongside their healthcare team. For clinicians, it enables targeted care rather than reactive treatment. For families, it offers something previously unavailable: time.

By shifting pre-eclampsia care from crisis response to early prevention, this research has the potential to save lives and reduce long-term complications for mothers and babies alike.

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